Jessica Spina began her career in 1992 working as a financial analyst covering the Italian banking sector. She joined Mediobanca in 1998, working as part of the M&A FIG team, working on the leading bank privatizations in course at the time. From the start of her time in Mediobanca she has worked on strategic planning and developing strategic plans for the Group.

Jessica Spina launched the Group's Investor Relations activity in 2004, gradually expanding her area of responsibility from relations with institutional investors to ratings agencies, proxy advisors, and institutional financial communication..

Jessica Spina, already Head of  Group Strategic Corporate Development since 2011, is nominated Chief Strategy Officer in 2023.